There are many factors that affect the operation stability of the argon system of the air separation plant, so the operating conditions of the argon regulation of the air separation plant should be fully considered. If there is a fault in the operation of the equipment, it is necessary to find out the cause of the fault and take corresponding measures, but it is also necessary to avoid frequent and large-scale adjustment of the working conditions. The argon regulation of air separation plant needs to be more refined, pay attention to the change of each index, keep clear thinking, and adjust patiently and carefully.