Expanded perlite, a special pearlite for air separation unit, is widely used in large, medium and small air separation units, and has become a good thermal insulation material for air separation cold box and liquefied gas storage tank. With the large-scale air separation unit, the capacity of pearlite filled in the cold box is also increased. Therefore, attention should be paid to the safety problems during the loading and unloading of pearlite to avoid accidents.