The operation cost of air separation unit mainly consists of three parts: operation energy consumption, spare parts and maintenance costs and personnel expenses. When selecting the air separation unit, it is necessary to consider that the energy consumption of the internal compression process is slightly higher, because of the high liquid production, these cooling capacity can not be recovered; the spare parts of the internal compression process need to be imported with high price; at the same time, the maintenance cost is low and the operators are few. We should choose according to the actual situation of the enterprise.