Impeller is the core component of compressor. The leading compressor manufacturers in the world all implement technical blockade on the key manufacturing process of closed three-dimensional impeller. Three dimensional closed impeller is widely used in large compressors. Because of its large degree of distortion, narrow channel and large curvature of the rotating surface of the shaft disc and cover disc, it is difficult to solve the problem by using general processing technology. Previously, only a few countries in the world mastered the technology, while China's closed impeller integral milling technology is still a blank. On the basis of the original five axis machining process of impeller, the unit developed the special process software for Impeller Based on five axis machining center, and studied the corresponding cutter types and processing parameters of each process, solved the technical difficulties of integral milling processing of high-strength three-dimensional closed impeller, improved the manufacturing accuracy of impeller, and accelerated the development progress of products, It meets the needs of new product development of large compressor.