The operation method of air separation unit should be determined according to different unit models and work processes, and the suitable operation mode should be summarized in the actual work. The operation of the air separation unit generally includes the optimization and adjustment of the unit in normal operation, the emergency response under the condition of unit failure, and the start-up and shutdown of the air separation unit. The operation method of air separation unit should also refer to the manufacturer's operating procedures and operate in strict accordance with the regulations to avoid failure.